The series of experiments with L. E. E., in which only the chair calorimeter was used, extended over a relatively short period of time - i. e., from March 14 to May 11, 1910. (See table 32.) The average values for both the carbon-dioxide production and the oxygen consumption agree very well with those found with the subjects previously considered. Those for the heat production show a striking disagreement with each other, the high value of 81 calories being found for the first hour, while a low value of 68 calories is found in the third hour of one experiment. It is probable that these variations in the values for heat output are due to the fact that they have not been corrected for changes in body-temperature, as these measurements were not made; hence the heat values correspond to heat elimination rather than to heat production.

Table 32. - Basal Metabolism Of L. E. E. At Different Times Of Day In Chair-Calorimeter Experiments. Boston

(Values per hour).

Date.

Observation and duration.

First hour.1

Second horn*.

Third hour.

Average.

1910.

Carbon dioxide.

am.

am.

gm.

gm.

Mar. 14

9h23ma.m. to llh23ma.m.......................

28.5

25.5

27.0

May 3

8 40 a.m. to 10 40 a.m.......................

25.0

24.5

25.0

May 11

8 31 a.m. to 10 31 a.m.....................

25.0

24.0

24.5

Average.......

25.0

25.5

25.5

25.5

Oxygen.

Mar. 14

9h23ma.m. to llh23ma.m . ......

23.0

21.5

22.0

May 3

8 40 a.m. to 10 40 a.m....................

22.0

21.0

21.5

May 11

8 31 a.m. to 10 31 a.m.......................

22.0

21.5

21.5

Average................................

22.0

22.0

21.5

21.5

Heat

cats.

cals.

cals.

cats.

Mar. 14

9h23m a.m. to 11h23m a.m.....

272

268

270

May 3

8 40 a.m. to 10 40 a.m.......................

281

274

278

May 11

8 31 a.m. to 10 31 a.m...................

281

279

280

Average.................. ........

281

275

268

276

1The beginning of the "First hour" was for this subject approximately between 8h30m a. m. and 9h30m a. m. 2Heat eliminated corrected for change in body-weight, but not for change in body-temperature.

Another subject, V. G., who was measured in both the chair calorimeter and the bed calorimeter, was not temperamentally adapted for experimentation with such a fine point at issue as the influence of the ingestion of food. The basal values obtained with the chair calorimeter show larger variations from hour to hour than have thus far been noted with any of the subjects; indeed, the measurements of the heat output were lost in the experiment of January 21. (See table 33.) Measurements of the body-temperature were practically impossible with this subject and hence the use of the heat values for comparison with those obtained after food is questionable. The average results of the bed-calorimeter experiments show no great fluctuation, even for the heat output. With this subject, also, the average values found with the chair calorimeter are perceptibly higher than those found with the bed calorimeter.

Table 33. - Basal Metabolism Of V. G. At Different Times Of Day In Calorimeter Experiments. Boston

(Values per hour).

Date.

Observation and duration.

First hour.1

Second hour.

Third hour.

Fourth hour.

Average.

Chair Calorimeter.

gm.

gm.

gm.

gm.

gm.

1911.

Carbon dioxide.

Jan. 2

9h07ma.m. to 9h52ma.m...............

230.0

30.0

30.0

\ll 22 a.m. to 12 15 p.m...............

....

....

Jan. 21

8 55 a.m. to 10 25 a.m...............

228.5

229.5

.....

....

29.0

Average..........................

29.5

29.5

....

30.0

29.5

Oxygen.

Jan. 2

9h07ma.m. to 9h52ma.m...............

224.0

26.0

25.0

11 22 a.m. to 12 15 p.m...............

....

.....

Jan. 21

222.0

228.5

.....

25.5

Average ......................

23.0

28.5

....

26.0

25.5

Heat.

cola.

cals.

cals.

cals.

cals.

Jan. 2

9h07ma.m. to 9h52ma.m...............

286

379

383

11 22 a.m. to 12 15 p.m...............

....

Bed Calorimeter.

1910.

Carbon dioxide.

gm.

gm.

gm.

gm.

gm.

Oct. 24

9h39ma.m. to 12h39mp.m...............

23.0

24.5

24.0

24.0

Oct. 26

9 52 a.m. to 12 52 p.m...............

424.5

424.0

24.5

Nov. 4

9 26 a.m. to 11 56 a.m...............

423.5

24.0

24.0

Nov. 7

9 01 a.m. to 11 06 a.m...............

24.0

25.0

24.5

Dec. 19

9 12 a.m. to 11 27 a.m...............

226.5

224.5

226.0

....

25.5

Average .......................

25.5

24.0

24.5

24.0

24.5

Oxygen.

Oct. 24

9h39ma.m. to 12h39mp.m...............

20.0

22.5

21.0

21.0

Oct. 26

9 52 a.m. to 12 52 p.m...............

419.0

420.0

• • •

19.5

Nov. 4

9 26 a.m. to 11 56 a.m...............

420.5

20.5

.....

20.5

Nov. 7

9 01 a.m. to 11 06 a.m...............

19.0

19.0

19.0

Dec. 19

9 12 a.m. to 11 27 a.m...............

220.5

223.0

222.5

.....

22.0

Average .....................

20.0

20.5

21.5

21.0

20.5

Heat.

cals.

cals.

cals.

cals.

cals.

Oct. 24

9h39ma.m. to 12h39mp.m...............

361

369

»68

366

Oct. 26

9 52 a.m. to 12 52 p.m...............

466

467

....

267

Nov. 4

9 26 a.m. to 11 56 a.m...............

465

368

367

Nov. 7

9 01 a.m. to 11 06 a.m...............

264

364

....

364

Dec. 19

9 12 a.m. to 11 27 a.m...............

265

268

.....

367

Average .........................

364

364

368

368

366

1The beginning of the "First hour" for this subject was approximately between 9 a. m. and 9h45m a. m.

2Calculated to hour basis; measured in period of 45 minutes. The heat values are heat eliminated corrected for change in body-weight, but not for change in body-temperature.

3Heat eliminated corrected for change in body-weight, but not for change in body-temperature.

4Calculated to hour basis; measured in period of 1 1/2 hours. Heat not corrected for change in body-temperature.

The subject T. M. C, thoroughly aware of the importance of uniform muscular activity, gives us values in chair-calorimeter experiments that are probably as accurate and consistent as can be expected with any subject. (See table 34.) They show but few deviations from the normal value for both the carbon-dioxide production and the oxygen consumption. As no measurements of the body-temperature were made, the usual variations in the measurements of the heat output appear. The average results show a remarkable constancy in the metabolism from hour to hour. The period of experimentation was short, being only from January 3 to January 12,1911, and no marked differences are found from day to day. The low metabolism noted in the whole series is in large part explained by the small body-weight of the subject.

Four other subjects, A. G. E., C. H. H., Dr. H., and D. J. M., were studied in the chair calorimeter for two 1-hour periods; the results of these few experiments are also given in table 34. As a rule, the values obtained show the usual uniformity from hour to hour.

Table 34. - Basal Metabolism At Different Times Of Day In Chair-Calorimeter Experiments

Boston. (Values per hour.)1

Subject and observation.

Date.

Duration.

First hour.2

Second hour.

Third hour.

Fourth hour.

Average.

T. M. C.

1911.

gm.

gm.

gm.

gm.

gm.

Carbon dioxide.

Jan. 3

8h25ma.m. to 9h58ma.m. ..

19.0

19.0

....

....

19.0

Jan. 7

8 43 a.m. to 10 15 a.m. ..

|l9.0

18.5

18.0

18.5

\ll 45 a.m. to 12 30 p.m...

....

Jan. 12

8 55 a.m. to 10 25 a.m...

19.5

18.5

.....

19.0

Average.............

19.0

18.5

....

18.0

19.0

Oxygen.......

Jan. 3

8h25ma.m. to 9h58ma.m...

17.5

18.0

18.0

Jan. 7

8 43 a.m. to 10 15 a.m...

l6.5

17.0

17.0

17.0

11 45 a.m. to 12 30 p.m...

....

Jan. 12

8 55 a.m. to 10 25 a.m. ..

16.5

17.5

....

.....

17.0

Average.............

17.0

17.5

17.0

17.5

calx.

cals.

cals.

cals.

cals.

Heat.........

Jan. 3

8h25ma.m. to 9h58ma.m.. .

366

360

363

Jan. 7

8 43 a.m. to 10 15 a.m...

156

355

356

356

\ll 45 a.m. to 12 30 p.m...

....

Jan. 12

8 55 a.m. to 10 25 a.m. . .

366

358

.....

....

362

Average.............

363

»58

.....

356

360

1Values for T. M. C. calculated to hour basis; measured in periods of 45 minutes.

2The beginning of the "First hour" was approximately between 8h30m a. m. and 9 a. m.

3Heat eliminated corrected for change in body-weight but not for change in body-temperature.

Subject and observation.

Date.

Duration.

First hour.1

Second hour.

Third hour

Fourth hour.

Average.

A. G. E.

1911.

gm.

gm.

gm.

gm.

gm.

Carbon dioxide

Jan. 23

8h47ma.m. to 10h47ma.m. ..

224.5

224.0

24.5

Oxygen...

Jan. 23

8 47 a.m. to 10 17 a.m...

222.0

221.0

21.5

cals.

cals.

cals.

cals.

cals.

Heat..........

Jan. 23

8 47 a.m. to 10 17 a.m. . .

272

271

....

372

C. H. H.

gm.

gm.

gm.

gm.

gm.

Carbon dioxide

Jan. 18

8h58ma.m. to 10h28ma.m. ..

222.0

222.0

22.0

Oxygen...

Jan. 18

8 58 a.m. to 10 28 a.m. ..

220.0

219.5

20.0

cals.

cals.

cals.

cals.

cals.

Heat..........

Jan. 18

8 58 a.m. to 10 28 a.m. . .

260

260

360

Dr. H.4

1910.

gm.

gm.

gm.

gm.

gm.

Carbon dioxide

Feb. 14

9h24ma.m. to llh24ma.m. ..

23.0

21.5

22.0

Feb. 17

9 31 a.m. to 11 31 a.m. . .

21.5

21.5

.....

21.5

Average.............

22.0

21.5

22.0

Oxygen...

Feb. 14

9h24ma.m. to llh24ma.m. . .

20.5

19.5

20.0

Feb. 17

9 31 a.m. to 11 31 a.m. . .

20.0

20.5

20.5

Average.............

20.5

20.0

20.5

D. J. M.

gm.

gm.

gm.

gm.

gm.

Carbon dioxide

Mar. 23

9h33ma.m. to llh33ma.m. ..

25.5

25.5

25.5

June 3

9 37 a.m. to 11 37 a.m. . .

25.5

24.5

25.0

June 7

9 21 a.m. to 11 21 a.m. ..

....

25.5

26.0

....

26.0

Average ................

25.5

25.5

25.5

Oxygen........

Mar. 23

9h33ma.m. to llh33ma.m. . .

20.5

22.0

21.0

June 3

9 37 a.m. to 11 37 a.m. . .

20.5

20.5

20.5

June 7

9 21 a.m. to 11 21 a.m. . .

21.5

20.5

21.0

Average.............

21.0

21.0

21.0

cals.

cals.

cals.

cals.

cals.

Heat....

Mar. 23

9h33ma.m. to llh33ma.m. . .

368

372

■ • ■ •

370

June 3

9 37 a.m. to 11 37 a.m. ..

76

76

76

June 7

9 21 a.m. to 11 21 a.m. ..

382

378

380

Average.............

75

75

....

75

1The beginning of the "First hour" was for the subjects in this table approximately between 8h30m a. m. and 9 a. m. 2Calculated to hour basis; measured in period of 45 min. The heat values for subjects A. G. E., and C. H. H., are heat eliminated corrected for change in body-weight, but not for change in body-temperature. 3Heat eliminated corrected for change in body-weight, but not for change in body-temperature. 4The heat measurements for the experiments with this subject were technically defective.

A summary of the values for the basal metabolism found with the subjects of the Boston calorimeter experiments is given in table 35. With two subjects we have values obtained with both the chair and bed calorimeters, which show that the metabolism in the chair calorimeter is perceptibly higher than that in the bed calorimeter. The difference is so much greater than that which would commonly be expected, and also greater than that shown in an earlier report from this laboratory,1 that it must be considered as due not merely to a difference in body position but also to an admittedly somewhat more liberal muscular activity in the chair calorimeter as compared with that in the bed calorimeter. Undue stress must not be laid upon the rather remarkable agreement in the values for the heat output with the subjects J. R., F. M. M., L. E. E., D. J. M., and J. J. C, in the experiments with the chair calorimeter or upon the extraordinarily low values obtained with C. H. H. and A. G. E., for the fact that the body-temperature measurements were lacking in many of the experiments plays an important role in the interpretation of these values.

Table 35. - Summary Of Average Values For Basal Metabolism Determined For Subjects In Calorimeter Experiments. Boston

(Amounts per hour).

Subject.

Calorimeter.

Average body-weight without clothing.

Carbon dioxide.

Oxygen.

Heat,

Nitrogen1 excreted in urine.

kilos.

grams.

grams.

cals.

grams.

J. R............

Chair .

68.3

27.0

23.0

77

0.46

F. M. M........

Chair

60.2

25.5

22.5

77

.43

J. J. C..........

Chair.....

64.8

25.5

21.5

78

.40

Bed..............

63.5

22.5

19.0

265

L. E. E..........

Chair

59.5

25.5

21.5

276

.52

V. G............

Chair

55.8

29.5

25.5

283

35

Bed.........

53.3

24.5

20.5

266

T. M. C.........

Chair...

47.7

19.0

17.5

260

.41

A.G.E.......

Chair.....

56.4

24.5

21.5

272

.42

C. H. H.........

Chair

54.8

22.0

20.0

260

».36

Dr.H..........

Chair........

66.3

22.0

20.5

.32

D. J. M.........

Chair.......

58.1

25.5

21.0

75

.51

1Includes all nitrogen obtained with these subjects for the periods in which the basal metabolism was determined and during any other periods without food. (See table 36).

2Heat eliminated corrected for change in body-weight, but not for change in body-temperature.

3Subject was without food in first 3 hours of the 5 hours covered by each sample included in this average. Sucrose was given at the end of 3 hours.