An inspection of tables 126 to 168 shows that the typical picture of a marked increase in the carbon-dioxide production appears in practically every case. The increment in the oxygen consumption, although not so large as that for the carbon-dioxide production, also appears in most of the experiments. Naturally the values for the heat production, computed from the gaseous exchange, show corresponding increments. The increase in the carbon-dioxide production is paralleled by a marked rise in the respiratory quotient which, in a large number of periods, exceeds unity. This is in harmony with the results obtained in the calorimeter experiments, for although it was not feasible to discuss the respiratory quotients for those experiments, since the basal respiratory quotients for the same day were not obtained in many cases, we may note that most of the quotients after the ingestion of carbohydrate showed a value of 0.90 or above. Since the average respiratory quotient of normal man in the post-absorptive condition is not far from 0.83, it is obvious that these quotients above 0.90 substantiate the general observation that the respiratory quotient after carbohydrate ingestion is usually decidedly increased.

In the computation of the heat production from the oxygen consumption and the respiratory quotient, a difficulty is immediately encountered in the fact that the respiratory quotient is frequently over 1, especially the non-protein respiratory quotient. Experimental evidence as to the calorific value of oxygen and carbon dioxide under these conditions is much needed. An investigation of this problem is now in progress in this laboratory; pending its completion we have assumed, in common with other investigators, that when the quotient is above 1, the calorific values of carbon dioxide and oxygen are the same as those when the quotient is 1. The computations of the heat production were based entirely upon the oxygen consumption, since the carbon-dioxide excretion is greatly increased as a result of intermediary metabolism, with a possible splitting off of carbon dioxide accompanied by only minor increases in the production of heat.