This publication is the second edition of a thesis that Dr. Carl Dapper published eight years ago from my clinic (Zeitschrift fur klin. Med., vol. xxx., 1896). The investigations that were published in this first edition were carried out conjointly by Dr. Dapper and myself from 1894 to 1896. Later these studies were continued by both of us according to a definite plan, Dr. Dapper carrying on his investigations on numerous patients who visited his sanitarium in Kissingen, I on the patients of the Municipal Hospital in Frankfort, and my private patients. These later investigations simply corroborate and amplify our original studies.

In view of the great interest that balneological methods of treatment are exciting nowadays, the results of these investigations may herewith be given to a wider circle of readers, in the expectation that they will be a welcome addition to our therapeutic armamentarium.

(Signed) Professor von Noorden.

Frankfort-on-the-Main, February 20, 1904.