Beriberi

The story up to 1913 is discussed by E. P. Vedder in book on beriberi. C. Eijkman's classical paper appeared in the Archiv fur patholo-gische Anatomie, volume 149, page 197, 1897. Scarcely less important are the papers by Funk and co-workers (Journal of State Medicine, June, 1912, page 1; Lancet, page 1266, 1911; Journal of Physiology, volume 43, page 395,1911; Biochemical Journal, volume 8, page 598, 1914). See also the papers by W. P. Chamberlain and others, Philippine Jour nal, volume 6, number 3, section B, medical sciences, June, 1911, page 177; A. Harden and S. S. Zilva, Biochemical Journal, volume 11, page 172, 1917; H. Chick and E. M. Hume, Proceedings of the Royal Society, section B, volume 60, 1917; A. R. Leggale, Edinburgh Journal of Medicine, volume 24, page 32,1920; and A. D. Emmet and G. O. Luros, Journal of Biological Chemistry, volume 43, pages 265 and 287,1920.

Scurvy

An exhaustive treatise is the very recent publication of A. F. Hess: Scurvy Past and

Present (J. B. Lippincott Co., Philadelphia. 1920). In this country Drs. McCollum and Hess have done much experimental work on scurvy. Dr. Mc-Collum's papers are included in those quoted under "Summary." A summary of Dr. Hess's researches is given in the Journal of the American Medical Association, September 21, 1918, page 941. Among English investigators, Drs. Harden and Chick stand out prominently. Accounts of their work may be found in the Biochemical Journal, volume 12, pages 131 and 270, 1918, and volume 13, page 199, 1919. The effect of heat on the water-soluble C vitamine is discussed by E. M. Delf and R. F. Skelton in the Biochemical Journal, volume 12, page 448, 1918. A useful survey is that drawn up by the food (war) committee of the Royal Society, published in Lancet, Nov. 30, 1919, page 756.

Rickets

Early suggestions that rickets might be due to a deficiency in the vitamine content of the food consumed were made by Hopkins (Analyst, volume 31, page 395, 1906) and Funk {Die Vitamine, 1914). The papers by McCollum,, Osborne and Mendel quoted above discuss the fat-soluble A vitamine, particularly in reference to the eye disease xerophthalmia. Much of the clinical work in this country has been done by Hess and co-workers (Journal of the American Medical Association, page 1583, 1917; page 900, 1918, and page 218, 1920). In England Dr. Mellanby has been an active worker (see Lancet, March 15, 1919, page 407).

Pellagra

The most important work on this subject is by Dr. Goldberger and his associates (see the Washington Public Health Reports, volume 31, page 3159,1916, volume 33, page 481,1918; Journal of the American Medical Association, page 944, 1918; and Archives of Internal Medicine, volume 25, page 421,1920). Historically, the paper by Funk (Journal of Tropical Medicine, volume 6, page 166, 1913) is of extreme interest. Dr. McCollum's contributions should also be consulted (Journal of Biological Chemistry, volume 32, pages 29, 171 and 347, 1917; volume 30, page 13, 1917; and the American Journal of Physiology, volume 41, pages 333 and 361, 1917).

The nursing mother. Infant feeding. Consult J. L. Morse and F. B. Talbot: Diseases of Nutrition and Infant Feeding (Macmillan & Co., New York, 1920). The scarcity of the antiscorbutic factor in milk is discussed by Hess and Fish, American Journal of Diseases of Children, volume 8, page 385, 1914; and by Chick and Hume, Biochemical Journal, volume 12, page 131, 1918. See also the excellent pamphlet distributed by the Connecticut Agricultural Experiment Station, New Haven, Conn., entitled The Food Value of Milk (prepared by E. L. Ferry. Bulletin 215, December, 1919). The London Local Government Food Reports discuss dried milk in infant feeding (report No. 84, 1918) and proprietary infants' food (report No. 20, 1914). The value of dried milk is also the subject of critical comment in an article by E. M. Hume and R. S. Barnes, Biochemical Journal, volume 13, page 306, 1919. See also the article by Dr. W. N. Bradley on Feeding the New-born (Archives of Pediatrics, volume 37, page 144, 1920); and the discussion by Dr. Mellanby and others (Proceedings of the Royal Society of Medicine, volume 13, section of diseases of children, page 77, 1920).

Vitamine content of different foods. The table given on page 191 of this book should prove useful. The article by M. Davies and collaborators (Journal of Home Economics, volume 12, page 207,1920) should also be consulted. Attempts at quantitative estimations are discussed in the paper by W. H. Eddy and H. C. Stevenson, Journal of Biological Chemistry, volume 43, page 295, 1920.

Nomenclature

The suggestion that "vitamin" be substituted for "vitamine," because the ending "in," according to the English Chemical Society, represents a neutral substance of unidentified composition, whereas the "ine" terminology is associated with a group of well-known organic substances, is made by J. C. Drummond, Biochemical Journal, volume 14, page 660, 1920.

Clinical Symptoms

The clinical symptoms of the various diseases discussed in this book are de-scribed in various books dealing with the practice of medicine. One of the best known of these is Sir William Osier's The Principles and Practice of Medicine (D. Appleton & Co., New York, 1920).

Miscellaneous

McCollum and Simmonds: The American Home Diet (Frederick C. Mathews Co., Detroit, 1920).

Vernon Kellog and A. E. Taylor: The Food Problem (Macmillan & Co., New York, 1917),

Graham Lusk: The Fundamental Basis of Nutrition (Yale University Press, New Haven, 1915).

J. R. Smith: The World's Food Resources (Henry Holt & Co., New York, 1919).

E. H. Starling: The Feeding of Nations (Longmans, Green & Co., London, 1919).

L. J. Henderson: The Fitness of the Environment (Macmillan & Co., New York, 1913).

A. W. McCann: The Famishing World (George H. Doran & Co., New York, 1918).

H. D. Chapin: "How the Pediatric Teaching of Nutrition May Affect the Nation's Welfare." Journal of the American Medical Association, August 7, 1920, page 364.

W. A. Brown: "A Study of the Malnutrition Among School Children." Journal of the American Medical Association, July 3, 1920, page 27.

H. C. Sherman: "Food Chemistry in the Service of Human Nutrition." Journal of Industrial and Engineering Chemistry, May, 1918, page 383.

J. R. Murlin: "Diet of the United States Army Soldiers." Journal of the American Medical Association, September 21, 1918, page 950.

Paul Roth: "The Civilian War Ration." Journal of the American Medical Association, September 21, 1918, page 952.

H. E. Dubin and M. J. Lewi: "The Preparation of a Stable Vitamine Product and Its Value in Nutrition." American Journal of Medical Sciences, February, 1920, page 1.

M. T. Wellman: "Recent Advances in Our Knowledge of Food Selection and Preparation."

Journal of Home Economics, January, 1920, page 15.

J. R. Murlin: "What We Have Learnt in Dietetics in the Army." Journal of Home Economics, March, 1920, page 97.

Chi Che Wang: "Is the Chinese Diet Adequate?" Journal of Home Economics, July, 1920, page 289.