It is seen from the foregoing that similar symptoms are produced by totally opposite conditions. In diabetes minor the glycogenic function of the liver is depressed, and it fails to convert the sugar brought by the portal vein into glycogen. In diabetes major the glycogenic function of the liver is abnormally excited, and the liver cells convert into glycogen even the nitrogenous elements of the muscles of the patient. It is a question whether we have not here to do with two totally different diseases, and that, owing to the presence of an identical symptom, viz., the presence of sugar in the urine, we do not err in submitting both classes of patients to the same regimen. In the first, the exclusion of starch and sugar is well borne; in the latter, the economy seems to cry out for sugar, in order to feed the rapacious voracity of the liver. The most, however, that can be done in cases of diabetes major is to relieve the sufferings of the patient, and to make the end as easy as possible.