In Albuminuria there is a marked tendency to depression and irritability. Worry and hypochondriasis are frequently due to renal disorders and these may increase to temporary mental aberration with suicidal tendency. In these states there is not only the element of toxemia, but also the general impoverishment of the tissues and blood serum from loss of albumin.

In acid intoxications the tendency to mental misery and suicide is very marked. Suicide may be from premeditation dependent upon long continued malaise, or it may be from mania in which the patient is insane and has no knowledge of his acts. Hypochondriacal melancholia may occur before an attack of gout and end promptly upon its appearance. The mania of the gouty is usually violent and dangerous and such patients chatter without ceasing, rapidly exhausting themselves.

It is hardly necessary to allude to the characteristic temperaments of the dyspeptic and gouty which are simply the result of the chronic depressant effects of these poisons upon the system and brain.