The Qualitative Impairment Of The Blood-Fibrin here again, as in the fibrin-crasis of a higher grade, serves to explain summarily the fact, that in individuals with blood impoverished in fibrin, - or even generally impoverished, - tubercle continues to become deposited. It has been elsewhere affirmed, and it is worthy of repetition here, that in such cases every atom of tuberculo-dyscrasial fibrin becomes expended in the formation of tubercle. This view clears up the seeming inconsistency of afiirming tubercle to be rooted in a fibrin-crasis, whilst florid tuberculosis is found to be associated with a deficiency in fibrin. It is the prevailing notion of mere excess in fibrin that we would impugn.

The tuberculous-crasis itself may, by various chances, become modified through a combination with other dyscrasial constitutions of the fluids, giving rise, at least in part, to the several known varieties of tubercle.

The tuberculous crasis is commonly protopathic. Frequently enough, however, it results from other crases. The conversion of typhus, of ex-anthematous hypinosis to the tuberculo-croupous/crasis is frequent, and of the greatest scientific and practical interest.

The tuberculous crasis results, through exhaustion of the fibrin, in a defibrinated condition of the blood, - in albuminosis. And, again, the albumen - upon which the wasted fibrin may be supposed to have ingrafted its own morbid character - may take up the work of exudation in the shape of acute, albuminous tubercle, of lardaceous infiltration of the liver, spleen, and kidneys, - of general albuminuria; - hydremia and anaemia being the final issue.

The corpses of the tuberculous, responding to the long-continued and copious expenditure of protein substances upon tubercle, present general emaciation, with consumption of the fat and of the bone-medulla; - flabbiness, wasting, pallor of the muscles; fatty infiltration of the liver, spleen, and kidneys; and lastly, oedema and dropsy. The blood, with a few scanty fibrinous coagula, is fluid, adhesive, dark-red; or else, with the exception of very inconsiderable soft coagula, it is thin, watery, of a pale-red, resembling water in which flesh has been steeped. Wherever abundant fibrin-coagula are met with, they present the characters proper to the fibrin-crasis, often in conjunction with tubercle-like concretions, which in their elementary composition fully harmonize with the tubercle of exudation, that is, the tubercle of the textures.