Gangrene of the liver is very rare, in fact Ferrers and Berard deny its occurrence, but we have seen it in one well-marked case, associated with pulmonary gangrene. It is developed in parts affected with inflammation and suppuration, not so much as a result of intense inflammation as of certain peculiar conditions, which cause a tendency to gangrenous degeneration. It occurs in more or less circumscribed spots, in which the parenchyma is dissolved into a brown or greenish-black pulp, which diffuses the characteristic odor of sphacelus. We find suppuration in the vicinity, which is the product of reactive inflammation, and which defines the boundaries of the mortified part.